LifespanAtlas
Cataloging the most promising treatments for extending healthy lifespan

A visual atlas of life-extending interventions explained clearly.

LifespanAtlas organizes preclinical longevity studies into a single, explorable interface – separating interventions with clear lifespan benefits from those that failed to move the needle, and tracking what’s still in preclinical trials.

Explore treatments that extend lifespan ↗
Interventions with lifespan benefit
16 cataloged so far
Interventions with no effect
40 negative or null results
Preclinical trials currently underway
10 ongoing or planned
Rapamycin
Small molecule
Mechanism
mTOR inhibitor
Strain
Mouse: UM-HET3
Median lifespan
♂+9% ♀+13%
Max lifespan
♂+9% ♀+14%
Dose
Mouse14 ppm in food
Age at start
Mouse: 20 months (late-life)
Explore the atlas
Browse by outcome to see which interventions moved the curve, which fell flat, and which are still being tested.
Beneficial interventions
Interventions where at least one well-powered mouse study shows a statistically significant increase in median and/or maximum lifespan.
  • Split by sex: separate ♂ and ♀ effect sizes.
  • Standardized mouse doses + illustrative “human” equivalents.
  • Sortable by mechanism, dose, and earliest cohort year.
Open Beneficial page ↗
No effect / null results
Compounds and regimens that looked promising on paper, but failed to extend lifespan in rigorous mouse studies.
  • Clearly labeled as No benefit measured or No consistent benefit.
  • Helps avoid survivorship bias in the longevity “hype cycle.”
  • Same structured cards and dose metadata as the Beneficial track.
Open No-Effect page ↗
In preclinical trials
Interventions currently being tested in preclinical models for aging-adjacent endpoints (healthspan, frailty, inflammatory markers, etc.).
  • Mouse data alongside preclinical trial status and primary endpoints.
  • Focus on study design, not marketing claims.
  • Flags interventions with conflicting or incomplete evidence.
10+ preclinical studies.
Open In-Trials page ↗
How LifespanAtlas builds each card

Under the hood, LifespanAtlas is a structured, code-driven view of the longevity literature – not a listicle and not a vibes-based ranking.

  • 1
    Curate and normalize studies. Mouse lifespan studies are manually curated, tagged by strain, sex, and cohort, and normalized into a consistent JSON schema.
  • 2
    Extract effect sizes and doses. Each cohort’s median and maximum lifespan change, dose, and age at start are recorded, preserving sex-specific results where available.
  • 3
    Compute human-readable summaries. We derive “human-years” style estimates and text summaries to make the mouse data more intuitive – always clearly labeled as illustrative.
  • 4
    Layer on model-assisted reasoning. A structured scoring framework (implemented in code) uses large language models to synthesize risk/benefit narratives and identify gaps or contradictions.
The goal is not to crown a miracle drug, but to map the territory – including the parts where the evidence is thin or flat.
What LifespanAtlas is – and isn’t
  • ✔ Is: A structured atlas of mouse longevity experiments, designed to make cross-study comparisons easier.
  • ✔ Is: A way to see which interventions have robust, sex-specific lifespan effects – and which don’t.
  • ✔ Is: A launchpad for further reading, not a final verdict on any compound.
  • ✖ Is not: A guide for self-medication, biohacking protocols, or investment advice.
  • ✖ Is not: A substitute for clinical trials, regulators, or medical professionals.
Important: All lifespan and “human-year” estimates are derived from controlled mouse studies and modeling assumptions. They do not imply that these interventions extend human lifespan, and many may never do so.

Mouse-only preclinical data; all “human” values are illustrative estimates and do not constitute medical or treatment advice. This site is for educational and entertainment purposes only. Always consult a qualified healthcare professional before considering any treatment, supplement, or off-label drug use.